Hypertension
I went to the doc today to have him look at my shoulder (I strained it pretty bad a few weeks ago and it still is aching). While there I checked in as usual through the nurse with BP, weight, you know the drill. Well for the last year I have been borderline hypertensive and this time my BP was 150/100! 
All of this this after losing 35 pounds and eating way healthier for the last three months. The doc decided to start me on meds (Lisinopril) to lower it. The meds he has me on are pretty nice (he said) with few if any side effects. The biggest one being a cough for 1 in 20. He told me that I may lose enough weight and get off of them, which is a good thing, but that I may have to be on them from now on. This is not a huge surprise. Both my mom and dad were hypertensive, as were three out of four of my grandparents. It was not so much a matter of if as a matter of when. 
I still have hope of lowering it enough with diet and exercise and am going to continue on that path regardless. Like I said I have lost 35 pounds so far. My big downfall is exercise. It is getting better, I am walking more and more, but there is still room for improvement.